| BioPhyZica,
Inc. is a start-up established to develop a new class of therapeutics
called "Capillary Sealing Therapuetics". These drugs are utilized
for the treatment of many diseases that are caused by tissue injury
and are char acterized
by increased capillary permeability/leak leading to detrimental
swelling/edema. These drugs are unique in that they act through
both biophysical as well as biochemical mechanisms. Most previous
drugs unsuccessfully attempted to attack the problem of this harmful
edema from only a biochemical mechanism. Extremely damaging edema
exists in many disease states, many of which represent significant
markets with unmet medical needs (i.e. stroke, sepsis, ARDS, cardio-pulmonary
bypass surgery, head injuries, etc). This new technology is based
on research performed at Columbia University by BioPhyZica co-founder
Dr. Bashir Zikria, as well as patents resulting from BioPhyZica's
independent research. This intellectual property portfolio, as well
as production barriers, will give the company broad proprietary
coverage in this new class of therapeutics.
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